Silva was substituted with an injury after just 10 minutes, following a poor challenge he committed and received a yellow card for, with Meunier coming on to replace him.
While the right-back's introduction was forced, it proved an inspired one as he thrashed in an amazing strike after 34 minutes following another terrible turnover from the Madrid defence as they looked to play the ball out from the back.
Meunier gave Madrid no time to react as he lashed a strike beyond Casilla to double PSG's advantage, and he would make it 3-0 not long after as he capitalised on more terrible defending to nudge the ball home after a scrap in the Madrid penalty area.
Marcelo scored Madrid's first-half consolation as the opening 45 minutes drew to a close, converting a penalty following a defensive handball to deny Kevin Trapp a clean sheet.
Zidane sent out a completely different team for the second half, with Marco Asensio, Martin Odegaard and Dani Carvajal all coming on, while he also called on his son, Enzo, who replaced Lucas Vazquez.
The new-look Madrid gave a better account of themselves, as PSG introduced former Madrid star Angel Di Maria for goalscorer Ikone, but they struggled to break down a compact Paris defence, making for a flat start to the pre-season schedule as Emery continued his flawless start to life with the French giants.